The Best Estrogen Blockers for Men: How Aromatase Inhibitors Work
By contrast, the aromatase inhibitors do not have oestrogenic effects, which has led to concern about possible detrimental effects to lipid profiles. Customers find the supplement effective and easy to swallow, reporting positive results with their estrogen levels and hormonal breakouts. The product helps with fat loss, with some customers losing up to 3 pounds in two weeks, and provides relief from muscle pain and breast tenderness. They experience increased energy levels, improved mood, and reduced mood swings, with one customer noting it helps with depression.
What is hormone receptor–positive breast cancer?
BCRF is also supporting research on alternatives to hormone therapy to help improve postmenopausal thrivers’ health and quality of life. Historically, estrogen was considered primarily a “female hormone” while testosterone was viewed as the quintessential male hormone. However, this view has changed based on science and we now know that estrogens are important for men. They are quite vital for erectile function, mood, bone mineral density and even muscle mass. Estrogen receptors are located in a variety of tissues within the male body including the penis, brain, bones, fat cells and muscle.
DIM: Is It Really An Aromatase Inhibitor?
(Clusiaceae) (mangosteen) were also strongly inhibitory against aromatase in microsomes 109. Worldwide breast cancer estimates included over one million incident cases and almost 400,000 deaths in the year 2000 1, 2. In the United States, over 178,000 women were expected to be diagnosed with breast cancer in 2007 with over 40,000 deaths occurring from the disease 3. In developed countries, mortality from breast cancer has recently begun to decline, primarily due to earlier detection and improved treatments 4, 5. There are clinical doses of scientifically proven ingredients like Eurycoma longifolia extract and organic ashwagandha extract, which reduce aromatase activity, protect cells, and support testosterone production. Muscle Force says its Estrotase estrogen blocker drives noticeable weight loss results as well as exciting muscle growth and healthy hormone levels.
- 7,8-Dihydroxyflavone (16) was tested four times and has shown strong to moderate activity in microsomal testing 121, 123.
- 75mg of arimistane helps fight estrogen conversion while 50mcg of vitamin D3, 45mg of magnesium, and 25mg of zinc promote lean muscle development, power, strength, and drive.
- Consequently, men with high estrogen may experience numerous symptoms, one of which is gynecomastia, aka “man boobs.”
Testosterone levels were 800 ng/dL but after 6 months of therapy his estradiol level rose to 500 pg/mL, the highest value I have ever seen. Estrogen production was so abnormal that I began a search for an estrogen secreting tumor which thankfully I didn’t find. Testosterone replacement therapy can also cause side effects including acne, fluid retention, high blood pressure, male infertility, worsening sleep apnea, blood clots, erythrocytosis and gynecomastia. Testosterone therapy is generally contraindicated in men with prostate cancer or breast cancer. Prostate and breast cancer cells can be stimulated by increasing testosterone.
As men age, they may experience a decline in testosterone levels, which can lead to a variety of symptoms such as decreased sex drive, fatigue, and decreased muscle mass. In some https://eastern.in/understanding-growth-hormone-functions-benefits-7/ cases, men may also experience an increase in estrogen levels, which can exacerbate these symptoms. Aromatase inhibitors are a class of drugs that can help to reduce the conversion of testosterone to estrogen, thereby reducing the symptoms of low testosterone. The possibility that SSRIs might, by inhibiting CYP2D6, slow the metabolism of tamoxifen and reduce its effectiveness is a concern given that as many as one-fourth of breast cancer patients experience clinical depression and may be treated with SSRIs. In addition, SSRIs are sometimes used to treat hot flashes caused by hormone therapy.
Potential Risks and Side Effects of Aromatase Inhibitors on TRT
Men with estrogen lack from aromatase deficiency are obese and dyslipidemic (37). Estradiol in fact, besides promoting visceral lipolysis and subcutaneous adipogenesis (38), favors liver secretion of cholesterol into the bile (39). Hence, estrogen treatment results in improved body composition and metabolic profile in post-menopausal women (37).